Kabukicho is a large 'red-light' district in the slums of Tokyo. It's home to thousands of restaurants, karaoke, clubs and bars. It's also home to a wide variety of underworld establishments that attract weirdos and gangsters en masse. It's the type of neighborhood where it's not surprising to see riot police walking casually down the street.
Most Tokyoites don't hesitate to go to restaurants or izakaya in the area. However, they certainly wouldn't want to live anywhere near Kabukicho.